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The Atlanta Research & Education Foundation is designed to facilitate collaborations between the Department of Veterans Affairs Medical Center in Atlanta and other institutions. We welcome your interest in our facility, personnel, and research capabilities.

Working with the larger research community, AREF is one of the leading foundations in the country devoted to improving research, education, and ultimately healthcare for our nation's Veteran population.

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Investigator: Samantha Yeligar
Phone: (404) 321-6111 ext. 202518
Primary Research Interest: Other
Description of Research: My project objectives are to: 1) elucidate the molecular mechanisms of chronic alcohol-induced alveolar macrophage oxidative stress which lead to phagocytic dysfunction, and 2) investigate therapeutic strategies to mitigate alcohol-induced lung immune dysregulation.
Relevance to VA: In critically ill patients, chronic alcohol misuse increases the risk for developing respiratory infections and Acute Respiratory Distress Syndrome (ARDS) by 2-4-fold. Of the 27 million veterans in the US, 55% consume alcohol and 29% report binge or heavy alcohol use. Thus, millions of veterans are have an increased risk of lung infections and ARDS due to alcohol misuse. A better understanding of the relationship between alcohol misuse and altered lung cell function may permit targeted strategies to attenuate lung derangements.

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