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| Investigator: |
Phone: (404) 321-6111 ext. 202518
Email: [email protected]
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| Primary Research Interest: |
Other |
| Description of Research: |
My project objectives are to: 1) elucidate the molecular mechanisms of chronic alcohol-induced alveolar macrophage oxidative stress which lead to phagocytic dysfunction, and 2) investigate therapeutic strategies to mitigate alcohol-induced lung immune dysregulation. |
| Relevance to VA: |
In critically ill patients, chronic alcohol misuse increases the risk for developing respiratory infections and Acute Respiratory Distress Syndrome (ARDS) by 2-4-fold. Of the 27 million veterans in the US, 55% consume alcohol and 29% report binge or heavy alcohol use. Thus, millions of veterans are have an increased risk of lung infections and ARDS due to alcohol misuse. A better understanding of the relationship between alcohol misuse and altered lung cell function may permit targeted strategies to attenuate lung derangements. |
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