Contents & Topics
Related Information
Collaborative Efforts
The Atlanta Research & Education Foundation is designed to facilitate collaborations between the Department of Veterans Affairs Medical Center in Atlanta and other institutions. We welcome your interest in our facility, personnel, and research capabilities.

Working with the larger research community, AREF is one of the leading foundations in the country devoted to improving research, education, and ultimately healthcare for our nation's Veteran population.

Read More


Investigator Profile Search Results

Save Profile to PDF
Investigator: Tamas Alexy
Phone: (404) 727-3754
Primary Research Interest: Internal Medicine
Description of Research: The endothelium, the innermost layer of cells in a vessel, is the primary transmitter of signals from the circulating blood to the cells deeper in the vascular wall. The ability of endothelial cells to communicate these signals is critical to vascular health. We aim to characterize a new means of communication between vascular cells. Our preliminary studies indicate that endothelial cells are able to release small RNA molecules, called microRNAs, into the blood, which can ultimately be taken up by distant cells. We hypothesize that the release of microRNAs is determined by local blood flow conditions. Our work will: 1) provide insight into how vascular cells communicate; 2) identify new blood markers for disease; 3) potentially lead to the development of novel therapeutic strategies for disease prevention.
Relevance to VA: Our studies are aimed at investigating intercellular communication between endothelial cells, to identify new blood markers for atherosclerosis and, ultimately, to develop novel therapeutic strategies to reduce the incidence of cardiovascular diseases. While atherosclerotic vascular diseases are the leading cause of death nationwide, they are especially prevalent in the Veteran population. When successful, the project is expected to have a significant impact on the cardiovascular health of Veterans.

Return to List

Return to Search Form

Copyright © 2024 AREF. All Rights Reserved.     Privacy Statement      Support